https://doi.org/10.4081/btvb.2023.105
Artificial intelligence and machine learning in hemostasis and thrombosis
Submitted: 21 December 2023
Accepted: 17 January 2024
Published: 31 January 2024
Accepted: 17 January 2024
Abstract Views: 1760
PDF: 338
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Artificial intelligence (AI) is rapidly becoming more important in our daily lives, and it’s beginning to be used in life sciences and in healthcare. AI and machine learning (ML) models are just starting to be applied in the field of hemostasis and thrombosis, but there are already many examples of how they can be useful in basic research/pathophysiology, laboratory diagnostics, and clinical settings. This review wants to shortly explain how AI works, what have been its uses in hemostasis and thrombosis so far and what are possible future developments. Besides the great potential advantages of a correct application of AI to the field of hemostasis and thrombosis, possible risks of inaccurate or deliberately mischievous use of it must be carefully considered. A close monitoring of AI employment in healthcare and research will have to be applied over the next years, but it is expected that the appropriate employment of this new revolutionary technology will bring great advances to the medical field, including to the hemostasis and thrombosis area. The current review, addressed to non-experts in the field, aims to go through the applications of AI in the field of hemostasis and thrombosis that have been explored so far and to examine its advantages, drawbacks and future perspectives.
Rashidi HH, Bowkers KA, Reyes Gil M. Machine learning in the coagulation and hemostastis arena: an overview and evaluation of methods, review of literature, and future directions. J Thromb Haemost 2023;21:728-43.
DOI: https://doi.org/10.1016/j.jtha.2022.12.019
Yala A, Mikhael PG, Lehman C, et al. Optimizing risk-based breast cancer screening policies with reinforcement learning. Nat Med 2022;28:136-43.
DOI: https://doi.org/10.1038/s41591-021-01599-w
Peréz-Sanchéz L, Patiño-Trives AM, Aguirre-Zamorano MA, et al. Characterization of antiphospholipid syndrome atherothrombotic risk by unsupervised integrated transcriptomic analyses. Arterioscler Thromb Vasc Biol 2021;41:865-77.
DOI: https://doi.org/10.1161/ATVBAHA.120.315346
Kempster C, Butler G, Kuznecova E, et al. Fully automated platelet differential contrast image analysis via deep learning. Sci Rep 2022;22:4614.
DOI: https://doi.org/10.1038/s41598-022-08613-2
Bostani A, Mirzaeibonekhater H, Najafi H, et al. MLP-RL-CRD: diagnosis of cardiovascular risk in athletes using a reinforcement learning-based multilayer perceptron. Physiol Meas 2023;44.
DOI: https://doi.org/10.1088/1361-6579/ad1459
Rösler W, Altenbuchinger M, Baeßler B, et al. An overview and a roadmap for artificial intelligence in hematology and oncology. J Cancer Res Clin Oncol 2023;149:7997-8006.
DOI: https://doi.org/10.1007/s00432-023-04667-5
Singh D, Singh B. Investigating the impact of data normalization on classification performance. Appl Soft Comput J 2020;97:105524.
DOI: https://doi.org/10.1016/j.asoc.2019.105524
Zhou Y, Yasumoto A, Huang CJ, et al. Intelligent classification of platelet aggregates by agonist type. Elife 2020;9:e52938.
DOI: https://doi.org/10.7554/eLife.52938
Veninga A, Baaten CCFMJ, De Simone I, et al. Effects of platelet agonists and priming on the formation of platelet populations. Thromb Haemost 2022;122:726-38.
DOI: https://doi.org/10.1055/s-0041-1735972
Wang P, Sheriff J, Zhang P, et al. A multiscale model for shear-mediated platelet adhesion dynamics: correlating in silico with in vitro results. Ann Biomed Eng 2023;51:1094-97.
DOI: https://doi.org/10.1007/s10439-023-03193-2
Fang K, Dong Z, Chen X, et al. Using machine learning to identify clotted specimens in coagulation testing. Clin Chem Lab Med 2021;59:1289-97.
DOI: https://doi.org/10.1515/cclm-2021-0081
Yoon GJ, Heo JN, Kim M, et al. Machine learning-based diagnosis for disseminated intravascular coagulation (DIC): development, external validation, and comparison to scoring systems. PLoS One 2018;13:e0195861.
DOI: https://doi.org/10.1371/journal.pone.0195861
Marcucci R, Berteotti M, Gori AM, et al. Heparin induced thrombocytopenia: position paper from the Italian Society on Thrombosis and Haemostasis (SISET). Blood Transfus 2021;19:14-23.
Nilius H, Cuker A, Haug S, et al. A machine learning model for reducing misdiagnosis in heparin-induced thrombocytopenia: a prospective, multicentre, observational study. EClinical Medicine 2022;55:101745.
DOI: https://doi.org/10.1016/j.eclinm.2022.101745
Bury L, Gresele P. The amazing genetic complexity of anucleated platelets. Bleeding, Thrombosis and Vascular Biology 2022;1:33.
DOI: https://doi.org/10.4081/btvb.2022.33
Antunes-Ferreira M, D'Ambrosi S, Arkani M, et al. Tumor-educated platelet blood tests for non small cell lung cancer detection and management. Sci Rep 2023;13:9359.
DOI: https://doi.org/10.1038/s41598-023-35818-w
De Girolamo G, Sarti L, Cecoli S, et al. Safety and efficacy of treatment with vitamin K antagonists in patients managed in a network of anticoagulant services or a routine general care. Bleeding, Thrombosis and Vascular Biology 2022;1:9.
DOI: https://doi.org/10.4081/btvb.2022.9
Goto S, Pieper KS, Bassand JP, et al. New artificial intelligence prediction model using serial prothrombin time international normalized ratio measurements in atrial fibrillation patients on Vitamin-K antagonists: GARFIELD-AF. Eur Heart J Cardiovasc Pharmacother 2020;6:301-9.
DOI: https://doi.org/10.1093/ehjcvp/pvz076
Labovitz DL, Shafner L, Reyes Gil M, et al. Using artificial intelligence to reduce the risk of nonadherence in patients on anticoagulation therapy. Stroke 2017;48:1416-9.
DOI: https://doi.org/10.1161/STROKEAHA.116.016281
Lee H, Kim HJ, Chang HW, et al. Development of a system to support warfarin dose decisions using deep neural networks. Sci Rep 2021;11:14745.
DOI: https://doi.org/10.1038/s41598-021-94305-2
Mora D, Nieto JA, Mateo J, et al; RIETE Investigators. Machine learning to predict outcomes in patients with acute pulmonary embolism who prematurely discontinued anticoagulant therapy. Thromb Haemost 2022;122:570-7.
DOI: https://doi.org/10.1055/a-1525-7220
Nafee T, Gibson CM, Travis R, et al. Machine learning to predict venous thrombosis in acutely ill medical patients. Res Pract Thromb Haemost 2020;4:230-7.
DOI: https://doi.org/10.1002/rth2.12292
Wang Q, Yuan L, Ding X, Zhou Z. Prediction and diagnosis of venous thromboembolism using artificial intelligence approaches: a systematic review and meta-analysis. Clin AppI Thromb Haemost 2021;27:1.
DOI: https://doi.org/10.1177/10760296211021162
Jabbour S, Fouhey D, Shapard S, et al. Measuring the impact of AI in the diagnosis of hospitalized patients: a randomized clinical vignette survey study. JAMA 2023;330:2275-84.
DOI: https://doi.org/10.1001/jama.2023.22295
Khera R, Simon MA, Ross JS. Automation bias and assistive AI: risk of harm from AI driven clinical decision support. JAMA 2023;220:2255-7.
DOI: https://doi.org/10.1001/jama.2023.22557
Dauerman HL, Turco JV, Fuster V. Artificial intelligence, Bob Dylan, and cardiovascular scholarship. J Am Coll Cardiol 2023;82:961-3.
DOI: https://doi.org/10.1016/j.jacc.2023.07.006
Menz BD, Modi ND, Sorich MJ, Hopkins AM. Health disinformation use case highlighting the urgent need for artificial intelligence vigilance. JAMA Intern Med 2024;184:9296.
DOI: https://doi.org/10.1001/jamainternmed.2023.5947
Sahni NR, Carrus B. Artificial intelligence in U.S. healthcare delivery. N Engl J Med 2023;389:348-58.
DOI: https://doi.org/10.1056/NEJMra2204673
Bodini M, Rivolta MW, Sassi R. Opening the black box: interpretability of machine learning algorithms in electrocardiology. Phil Trans A Math Phys Eng Sci 2021;379:20202053.
DOI: https://doi.org/10.1098/rsta.2020.0253
Petch J, Di S, Nelson W. Opening the black box: the promise and limitations of explainable machine learning in cardiology. Can J Cardiol 2022;38:204-13.
DOI: https://doi.org/10.1016/j.cjca.2021.09.004
Meng J, Xing R. Inside the “black box”: embedding clinical knowledge in data-driven machine learning for heart disease diagnosis. Cardiovasc Digit Health J 2022;3:276-88.
DOI: https://doi.org/10.1016/j.cvdhj.2022.10.005
Stark L. Medicine’s lessons for AI regulation. N Engl J Med 2023;389:2213-5.
DOI: https://doi.org/10.1056/NEJMp2309872
Rajpurkar P, Chen E, Banerjee O, Topol EJ. AI in health and medicine. Nat Med 2022;28:31-8.
DOI: https://doi.org/10.1038/s41591-021-01614-0
How to Cite
Gresele, P. (2024). Artificial intelligence and machine learning in hemostasis and thrombosis. Bleeding, Thrombosis and Vascular Biology, 2(4). https://doi.org/10.4081/btvb.2023.105
Copyright (c) 2024 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Most read articles by the same author(s)
- Stefania Momi, Giuseppe Guglielmini, Giulia Ciarroca Taranta, Elisa Giglio, Angela Monopoli, Paolo Gresele, A nitric oxide-donor pravastatin hybrid drug exerts antiplatelet and antiatherogenic activity in mice , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 2 (2022)
- Daniela Poli, Emilia Antonucci, Gualtiero Palareti, Roberto Facchinetti, Pietro Falco, Giuseppina Serricchio, Teresa Lerede, Lucilla Masciocco, Paolo Gresele, Sophie Testa, Major bleedings in mechanical prosthetic heart valves patients on Vitamin K antagonist treatment. Data from the PLECTRUM Study , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 2 (2022)
- Loredana Bury, Paolo Gresele, The amazing genetic complexity of anucleated platelets , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 2 (2022)
- Paolo Gresele, Synthetic platelets: can bioengineering realize in few years what evolution made in over 200 million years? , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 3 (2024)
- Roberto Mario Santi, Annamaria Fulghesu, Ezio Zanon, Erica De Candia, Elvira Grandone, Giancarlo Di Renzo, Claudia Succu, Valentina Tosto, Vincenzina Bruni, Paolo Gresele, Diagnosis and management of abnormal uterine bleeding in adolescence , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 1 (2024)
- Stefania Momi, Paolo Gresele, Blood platelets and Charles Darwin’s natural selection , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- Loredana Bury, Marco Malvestiti, Paolo Gresele, The 2024 Nobel prize in Medicine: impact on hemostasis and thrombosis research , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 3 (2024)
Similar Articles
- Luca Puccetti, Vincenzo Sammartano, Federico Caroni, Margherita Malchiodi, Paola Calzoni, Eleonora Franceschini, Lucrezia Galasso, Monica Bocchia, Safety of COVID-19 mRNA vaccination in patients with history of acquired hemophilia A: a case series , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 3 (2022)
- Vincenzo Sammartano, Adele Santoni, Elisabetta Zappone, Paola Calzoni, Daniela Fineschi, Eleonora Franceschini, Federico Caroni, Anna Sicuranza, Monica Bocchia, Luca Puccetti, A case of acquired factor XIII deficiency secondary to plasmablastic lymphoma , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- Betül Ünlü, Neha Joshi, Jamie M. O'Sullivan, Endothelial cell dysfunction in cancer: a not-so-innocent bystander , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Loredana Bury, Marco Malvestiti, Paolo Gresele, The 2024 Nobel prize in Medicine: impact on hemostasis and thrombosis research , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 3 (2024)
- Stefano Lancellotti, Monica Sacco, Maira Tardugno, Antonietta Ferretti, Raimondo De Cristofaro, The Von Willebrand factor-ADAMTS-13 axis: a two-faced Janus in bleeding and thrombosis , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 1 (2022)
- Guest Editors: Anna Falanga, Benjamin Brenner, Alok A. Khorana, Oral Communications and Posters , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Agnes Y.Y. Lee, Venous thromboembolism treatment in patients with cancer: reflections on an evolving landscape , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Nadim Tawil, Lata Adnani, Janusz Rak, Coagulome and tumor microenvironment: impact of oncogenes, cellular heterogeneity and extracellular vesicles , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Tiziano Barbui, Clonal hematopoiesis and inflammation: a link with thrombosis and malignancy , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 2 (2022)
- Giovanni de Gaetano, Well begun is half done , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 3 (2022)
You may also start an advanced similarity search for this article.
