https://doi.org/10.4081/btvb.2024.133

Role of platelet autophagy in cardiovascular diseases

Vol. 3 No. 2 (2024)
Submitted: 25 March 2024
Accepted: 7 August 2024
Published: 26 August 2024
Platelets, autophagy, thrombosis, spermidine, trehalose
Abstract Views: 582
PDF: 145
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Authors

Luca D'Ambrosio
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy.
Maurizio Forte
https://orcid.org/0000-0003-0739-0534
Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.
Giacomo Frati
https://orcid.org/0000-0003-2703-3761
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.
Sebastiano Sciarretta
sebastiano.sciarretta@uniroma1.it
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.

Platelet hyperactivity leads to thrombosis, the primary cause of cardiovascular and cerebrovascular adverse events. Emerging evidence suggests that autophagy plays a fundamental role in platelet function, both at baseline and in response to stress. Autophagy is an intracellular mechanism devoted to the removal and recycling of damaged cytoplasmic cargoes. Basal level of autophagy ensures physiological platelet aggregation and hemostasis. Autophagy is impaired in platelets isolated from subjects at high cardiovascular risk whereas autophagy stimulation reduces platelet hyperactivity, along with an overall amelioration of oxidative stress status. In this mini-review, we explore the current literature on the role of autophagy in platelet biology and its relevance as a therapeutic target for counteracting cardiovascular diseases.

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How to Cite

D’Ambrosio, L., Forte, M., Frati, G., & Sciarretta, S. (2024). Role of platelet autophagy in cardiovascular diseases. Bleeding, Thrombosis and Vascular Biology, 3(2). https://doi.org/10.4081/btvb.2024.133
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