https://doi.org/10.4081/btvb.2024.146
The intriguing association between cancer and congenital bleeding disorders
Submitted: 9 July 2024
Accepted: 4 November 2024
Published: 16 December 2024
Accepted: 4 November 2024
Abstract Views: 152
PDF: 46
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The relationship between congenital bleeding disorders and cancer is complex and multifactorial....
1. Liu CJ, Yu YB, Teng CJ, et al. Increased cancer risk in patients with haemophilia A: a nationwide population-based 14-year study in Taiwan. Haemophilia 2014;20:741–6.
DOI: https://doi.org/10.1111/hae.12450
2. Colonne CK, Favaloro EJ, Pasalic L. The intriguing connections between von Willebrand factor, ADAMTS13 and cancer. Healthcare (Basel) 2022;10:557.
DOI: https://doi.org/10.3390/healthcare10030557
3. Franchini M, Di Perna C, Santoro C, et al. Cancers in patients with von Willebrand disease: a survey from the Italian Association of Haemophilia Centres. Semin Thromb Hemost 2016;42:36–41.
DOI: https://doi.org/10.1055/s-0035-1564844
4. Darby SC, Kan SW, Spooner RJ, et al. Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood 2007;110:815–25.
DOI: https://doi.org/10.1182/blood-2006-10-050435
5. Tagliaferri A, Di Perna C, Santoro C, et al. Cancers in patients with hemophilia: a retrospective study from the Italian Association of Hemophilia Centers. J Thromb Haemost 2012;10:90–5.
DOI: https://doi.org/10.1111/j.1538-7836.2011.04566.x
6. Shetty S, Sharma N, Ghosh K. Epidemiology of hepatocellular carcinoma (HCC) in hemophilia. Crit Rev Oncol Hematol 2016;99:129–33.
DOI: https://doi.org/10.1016/j.critrevonc.2015.12.009
7. Zanon E, Porreca A, Simioni P. Haemophilia and cancer: a literature review. J Clin Med 2024;19;13:1770.
DOI: https://doi.org/10.3390/jcm13061770
8. Lee CA. The natural history of HIV disease in haemophilia. Blood Rev 1998;12:135–44.
DOI: https://doi.org/10.1016/S0268-960X(98)90011-X
9. Franchini M, Tagliaferri A, Rossetti G, et al. The Natural History of Hepatitis C Virus Infection in Hemophiliacs. Hematology 2001;6:135–42.
DOI: https://doi.org/10.1080/10245332.2001.11746564
10. Franchini M. Haemophilia and cancer: a personal perspective. Blood Transfus 2013;11:26-31.
11. Ragni MV, Belle SH, Jaffe RA, et al. Acquired immunodeficiency syndrome-associated non-Hodgkin’s lymphomas and other malignancies in patients with hemophilia. Blood 1993;81:1889–97.
DOI: https://doi.org/10.1182/blood.V81.7.1889.1889
12. Darby SC, Ewart DW, Giangrande PL, et al. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. Lancet 1997;350:1425–31.
DOI: https://doi.org/10.1016/S0140-6736(97)05413-5
13. Miesbach W, Seifried E. Does haemophilia influence cancer‐related mortality in HIV‐negative patients? Haemophilia 2010;17:55–60.
DOI: https://doi.org/10.1111/j.1365-2516.2010.02364.x
14. Colombo M, de Franchis R, Del Ninno E, et al. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 1991;325:675–80.
DOI: https://doi.org/10.1056/NEJM199109053251002
15. Altekruse SF, Henley SJ, Cucinelli JE, et al. Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. Am J Gastroenterol 2014;109:542–53.
DOI: https://doi.org/10.1038/ajg.2014.11
16. Huang YC, Tsan YT, Chan WC, et al. Incidence and survival of cancers among 1,054 hemophilia patients: a nationwide and 14-year cohort study. Am J Hematol 2015;90.
DOI: https://doi.org/10.1002/ajh.23947
17. Hassan S, Monahan RC, Mauser-Bunschoten EP, et al. Mortality, life expectancy, and causes of death of persons with hemophilia in the Netherlands 2001–2018. J Thromb Haemost 2021;19:645–53.
DOI: https://doi.org/10.1111/jth.15182
18. Plug I, Van Der Bom JG, Peters M, et al. Mortality and causes of death in patients with hemophilia, 1992–2001: a prospective cohort study. J Thromb Haemost 2006;4:510–6.
DOI: https://doi.org/10.1111/j.1538-7836.2006.01808.x
19. Franchini M, Lippi G, Montagnana M, et al. Hemophilia and cancer: A new challenge for hemophilia centers. Cancer Treat Rev 2009;35:374–7.
DOI: https://doi.org/10.1016/j.ctrv.2009.01.001
20. Tagalakis V, Tamim H, Blostein M, et al. Use of warfarin and risk of urogenital cancer: a population-based, nested case-control study. Lancet Oncol 2007;8:395–402.
DOI: https://doi.org/10.1016/S1470-2045(07)70046-3
21. Kakkar AK, Levine MN, Kadziola Z, et al. Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS). J Clin Oncol 2004;22:1944–8.
DOI: https://doi.org/10.1200/JCO.2004.10.002
22. Brüggemann LW, Versteeg HH, Niers TM, et al. Experimental melanoma metastasis in lungs of mice with congenital coagulation disorders. J Cell Mol Me 2008;12:2622–7.
DOI: https://doi.org/10.1111/j.1582-4934.2008.00316.x
23. Langer F, Amirkhosravi A, Ingersoll SB, et al. Experimental metastasis and primary tumor growth in mice with hemophilia A. J Thromb Haemost 2006;4:1056–62.
DOI: https://doi.org/10.1111/j.1538-7836.2006.01883.x
24. Dolan G. The challenge of an ageing haemophilic population. Haemophilia 2010;16:11–6.
DOI: https://doi.org/10.1111/j.1365-2516.2010.02287.x
How to Cite
Zanon, E. (2024). The intriguing association between cancer and congenital bleeding disorders. Bleeding, Thrombosis and Vascular Biology, 3(3). https://doi.org/10.4081/btvb.2024.146
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