https://doi.org/10.4081/btvb.2022.23

Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases

Vol. 1 No. 2 (2022)
Submitted: 1 March 2022
Accepted: 6 May 2022
Published: 23 May 2022
Thrombosis, Thrombocytopenia, Vaccine, SARS-CoV-2
Abstract Views: 3660
PDF: 250
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Authors

Rita Carlotta Santoro
ritacarlottasantoro@gmail.com
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Roberto Minici
Diagnostic Radiology Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Marzia Leotta
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Mariapia Falbo
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Lucia Concetta Elia
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Francesca Leo
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Antonella Ierardi
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Alessandra Strangio
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.
Simona Prejanò
Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro, Italy.

Vaccination with ChAdOx1 nCoV-19 can result in vaccine-induced immune thrombotic thrombocytopenia (VITT). This phenomenon mimics heparin-induced thrombocytopenia, yet it does not require heparin as a trigger. This case report highlights the potentially lifethreatening complication associated with ChAdOx1 nCov-19 vaccine, clinical presentation, diagnostic approach, and treatment. We report two cases of vaccine-induced immune thrombotic thrombocytopenia after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. We attribute these thrombotic conditions to the vaccine due to the remarkable temporal relationship. The proposed mechanism of VITT is a production of antibodies against platelet factor-4 resulting in massive platelet activation. Healthcare providers should be aware of the possibility of such a fatal complication, and the vaccine recipients should be warned about the symptoms of VITT.

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Marzia Leotta, Hemostasis and Thrombosis Center Unit, Azienda Ospedaliera Pugliese-Ciaccio, Catanzaro

 

 

How to Cite

Santoro, R. C., Minici, R., Leotta, M., Falbo, M., Elia, L. C., Leo, F., … Prejanò, S. (2022). Vaccine-induced immune thrombotic thrombocytopenia following AstraZeneca (ChAdOx1 nCoV-19) vaccine: report of two cases. Bleeding, Thrombosis and Vascular Biology, 1(2). https://doi.org/10.4081/btvb.2022.23
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