https://doi.org/10.4081/btvb.2022.24
The night of randomized clinical trials where all patients are black: a need to estimate variability in treatment effects
Published: 22 March 2022
Abstract Views: 1669
PDF: 233
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
In the Sixties, the few anti-thrombotic drugs available were administered following several criteria including tradition of the “School”, preference of the doctor in charge, pressure of pharmaceutical companies [...]
Peto R. Aspirin after myocardial infarction. Lancet 1980;1:1172-3.
DOI: https://doi.org/10.1016/S0140-6736(80)91626-8
Antithrombotic Trialists' Collaboration. Collaborative metaanalysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 2002;324:71-86. Erratum in: BMJ 2002;324:141.
DOI: https://doi.org/10.1136/bmj.324.7329.71
Sackett DL, Rosenberg WM, Gray JA, et al. Evidence based medicine: what it is and what it isn't. BMJ 1996;312:71-2.
DOI: https://doi.org/10.1136/bmj.312.7023.71
Liberati A. Need to realign patient-oriented and commercial and academic research. Lancet 2011; 378: 1777-8.
DOI: https://doi.org/10.1016/S0140-6736(11)61772-8
de Gaetano G, Cerletti C, Dejana E, Vermylen J. Current issues in thrombosis prevention with antiplatelet drugs. Drugs 1986;31:517-49.
DOI: https://doi.org/10.2165/00003495-198631060-00004
Roses AD. Pharmacogenetics and the practice of medicine. Nature 2000;405(6788):857-65.
DOI: https://doi.org/10.1038/35015728
Liuzzo G, Patrono C. Give genotype-guided dual antiplatelet therapy a second CHANCE. Eur Heart J 2022;43:938-9.
DOI: https://doi.org/10.1093/eurheartj/ehac024
Angus DC, Chang CH. Heterogeneity of treatment effect: estimating how the effects of Interventions vary across individuals. JAMA 2021;326:2312-3.
DOI: https://doi.org/10.1001/jama.2021.20552
Athey S, Imbens G. Recursive partitioning for heterogeneous causal effects. Proc Natl Acad Sci U S A 2016;113: 7353-60.
DOI: https://doi.org/10.1073/pnas.1510489113
Di Castelnuovo A, Gialluisi A, Antinori A, et al. Disentangling the association of hydroxychloroquine treatment with mortality in Covid-19 hospitalized patients through Hierarchical Clustering. J Healthc Eng 2021;2021:5556207.
DOI: https://doi.org/10.1155/2021/5556207
How to Cite
de Gaetano, G. ., Cerletti, C. ., Iacoviello, L. ., & Donati, M. B. . (2022). The night of randomized clinical trials where all patients are black: a need to estimate variability in treatment effects. Bleeding, Thrombosis and Vascular Biology, 1(1). https://doi.org/10.4081/btvb.2022.24
Copyright (c) 2022 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Most read articles by the same author(s)
- Augusto Di Castelnuovo, Licia Iacoviello, Moving beyond p-value , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 1 (2022)
- Giovanni de Gaetano, Well begun is half done , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 3 (2022)
- Roberta Parisi, Simona Costanzo, Romy de Laat-Kremers, Augusto Di Castelnuovo, Amalia De Curtis, Teresa Panzera, Mariarosaria Persichillo, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas de Laat , for the Moli-sani Study Investigators, Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- Giovanni de Gaetano, Welcome to AICE and sincere wishes for peace for the new year 2024 , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 4 (2023)
- Benedetta Izzi, Simona Costanzo, Alessandro Gialluisi, Amalia De Curtis, Sara Magnacca, Teresa Panzera, Augusto Di Castelnuovo, Maria Benedetta Donati, Chiara Cerletti, Marc F. Hoylaerts, Giovanni de Gaetano, Licia Iacoviello, *on behalf of the Moli-sani Study Investigators, Platelet distribution width is associated with cardiovascular mortality in an adult general population , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 3 (2023)
- Giovanni de Gaetano, Chiara Cerletti, Blood platelets, prostaglandins and aspirin: a historical and personal rereading , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 1 (2024)
- Marialaura Bonaccio, Licia Iacoviello, Maria Benedetta Donati, It’s definitely time to consider diet in its ultra-processing form as a major risk factor for thrombotic vascular disorders , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 3 (2023)
- Giovanni de Gaetano, Da la scheggia rotta usciva insieme parole e sangue: an unusual case of bleeding and the metaphor of a clinical trial , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 3 (2024)
- Giovanni de Gaetano, Science in Ukraine is “bleeding” , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- Giovanni de Gaetano, Artificial intelligence, platelets and aspirin , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 1 (2024)
Similar Articles
- Giovanni de Gaetano, Da la scheggia rotta usciva insieme parole e sangue: an unusual case of bleeding and the metaphor of a clinical trial , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 3 (2024)
- Daniela Poli, Riccardo Tartaglia, Doris Barcellona , Paolo Bucciarelli , Antonio Ciampa, Elvira Grandone, Giuseppe Malcangi, Giuseppe Rescigno, Vincenzo Toschi, Sophie Testa, Alessandro Squizzato, Attitude to clinical research among health professionals affiliated with the Italian Federation of Centers for the Diagnosis of Thrombotic Disorders and the Surveillance of the Antithrombotic Therapies (FCSA) , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- Nadim Tawil, Lata Adnani, Janusz Rak, Coagulome and tumor microenvironment: impact of oncogenes, cellular heterogeneity and extracellular vesicles , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Coenraad H. Hemker, The clinical usefulness of measuring thrombin generation , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
- Gualtiero Palareti, Paolo Prandoni, Cristina Legnani, Emilia Antonucci, Serena Zorzi, Alberto Tosetto, Lorenza Bertù, Sophie Testa, Vittorio Pengo, Walter Ageno, Ida Martinelli, Benilde Cosmi, Eugenio Bucherini, Daniela Poli, Rationale and design of a study on D-dimer use to stratify patients after a first unprovoked venous thromboembolism for their risk of recurrence: extended low-dose Apixaban given only to patients with positive D-dimer results , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 1 (2022)
- Marwa Eltemamy, Robert Namushi, Narayanamoorthi Saravanan, Importance of assessment of carotid plaques in the managementof acute ischemic stroke: floating intracarotid plaque , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 3 (2023)
- Giuseppe Camporese, Paolo Prandoni, Walter Ageno, Aspirin or low-molecular weight heparin for thromboprophylaxis after a fracture? That is the question , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 2 (2023)
- Anne Eichmann, The Lefoulon Delalande Foundation honors the lymphatic vascular system , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 4 (2023)
- Paolo Gresele, Artificial intelligence and machine learning in hemostasis and thrombosis , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 4 (2023)
- Massimo Franchini, Polycythemia vera and management of the thrombotic risk: an update , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 4 (2023)
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
