https://doi.org/10.4081/btvb.2022.33
The amazing genetic complexity of anucleated platelets
Submitted: 1 April 2022
Accepted: 9 June 2022
Published: 15 July 2022
Accepted: 9 June 2022
Abstract Views: 2009
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Rowley JW, Oler AJ, Tolley ND, et al. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood 2011;118:e101-11.
DOI: https://doi.org/10.1182/blood-2011-03-339705
Londin ER, Hatzimichael E, Loher P, et al. The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct 2014;9:3.
DOI: https://doi.org/10.1186/1745-6150-9-3
Kahr WH, Hinckley J, Li L, et al. Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nat Genet 2011;43:738-40.
DOI: https://doi.org/10.1038/ng.884
Weyrich AS, Dixon DA, Pabla R, et al. Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci USA 1998;95:5556-61.
DOI: https://doi.org/10.1073/pnas.95.10.5556
Lindemann S, Tolley ND, Dixon DA, et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol 2001;154:485-90.
DOI: https://doi.org/10.1083/jcb.200105058
Weyrich AS, Schwertz H, Kraiss LW, Zimmerman GA. Protein synthesis by platelets: historical and new perspectives. J Thromb Haemost 2009;7:241-6.
DOI: https://doi.org/10.1111/j.1538-7836.2008.03211.x
Denis MM, Tolley ND, Bunting M, et al. Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 2005;122:379-91.
DOI: https://doi.org/10.1016/j.cell.2005.06.015
Nassa G, Giurato G, Cimmino G, et al. Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications. Sci Rep 2018;8:498.
DOI: https://doi.org/10.1038/s41598-017-18985-5
Mills EW, Green R, Ingolia NT. Slowed decay of mRNAs enhances platelet specific translation. Blood 2017;129:e38-48.
DOI: https://doi.org/10.1182/blood-2016-08-736108
Cecchetti L, Tolley ND, Michetti N, et al. Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood 2011;118:1903-11.
DOI: https://doi.org/10.1182/blood-2010-12-324517
Bray PF, McKenzie SE, Edelstein LC, et al. The complex transcriptional landscape of the anucleate human platelet. BMC Genomics 2013;14:1.
DOI: https://doi.org/10.1186/1471-2164-14-1
Dahiya N, Sarachana T, Vu L, et al. Platelet MicroRNAs: an overview. Transfus Med Rev 2015;29:215-9.
DOI: https://doi.org/10.1016/j.tmrv.2015.08.002
Alhasan AA, Izuogu OG, Al-Balool HH, et al. Circular RNA enrichment in platelets is a signature of transcriptome degradation. Blood. 2016;127:e1-e11.
DOI: https://doi.org/10.1182/blood-2015-06-649434
Preußer C, Hung L-H, Schneider T, et al. Selective release of circRNAs in platelet-derived extracellular vesicles. J Extracell Vesicles 2018;7:1424473.
DOI: https://doi.org/10.1080/20013078.2018.1424473
Yan S, Liu X, Ke X, et al. Screening on platelet LncRNA expression profile discloses novel residual platelet reactivity biomarker. Int J Lab Hematol 2020;42:661-8.
DOI: https://doi.org/10.1111/ijlh.13261
Kaudewitz D, Skroblin P, Bender LH, et al. Association of MicroRNAs and YRNAs with platelet function. Circ Res 2016;118:420-32.
DOI: https://doi.org/10.1161/CIRCRESAHA.114.305663
Raghavachari N, Xu X, Harris A, et al. Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease. Circulation 2007;115:1551-62.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.658641
Lood C, Amisten S, Gullstrand B, et al. Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: upregulation of the type I interferon system is strongly associated with vascular disease. Blood 2010;116:1951-7.
DOI: https://doi.org/10.1182/blood-2010-03-274605
Eicher JD, Wakabayashi Y, Vitseva O, et al. Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. Platelets 2016;27:230-9.
DOI: https://doi.org/10.3109/09537104.2015.1083543
Davizon-Castillo P, McMahon B, Aguila S, et al. TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood 2019;134:727-40.
DOI: https://doi.org/10.1182/blood.2019000200
Campbell RA, Franks Z, Bhatnagar A, et al. Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in aging. J Immunol 2018;200:295-304.
DOI: https://doi.org/10.4049/jimmunol.1700885
Middleton EA, Rowley JW, Campbell RA, et al. Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood 2019;134:911-23.
DOI: https://doi.org/10.1182/blood.2019000067
Nührenberg TG, Stöckle J, Marini F, et al. Impact of high platelet turnover on the platelet transcriptome: Results from platelet RNA-sequencing in patients with sepsis. PLoS One 2022;17:e0260222.
DOI: https://doi.org/10.1371/journal.pone.0260222
Manne BK, Denorme F, Middleton EA, et al. Platelet gene expression and function in patients with COVID-19. Blood 2020;136:1317-29.
DOI: https://doi.org/10.1182/blood.2020007214
Ji W, Chen L, Yang W, et al. Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosis. Cell Biosci 2022;12:15.
DOI: https://doi.org/10.1186/s13578-022-00750-5
Marcantoni E, Allen N, Cambria MR, et al. Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity. JACC Basic Transl Sci 2018;3:9-22.
DOI: https://doi.org/10.1016/j.jacbts.2017.10.005
Campbell RA, Schwertz H, Hottz ED, et al. Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3. Blood 2019;133:2013-26.
DOI: https://doi.org/10.1182/blood-2018-09-873984
Zhang S, Liu Y, Wang X, et al. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. J Hematol Oncol 2020;13:120.
DOI: https://doi.org/10.1186/s13045-020-00954-7
Zaid Y, Puhm F, Allaeys I, et al. Platelets Can Associate with SARS-Cov-2 RNA and Are Hyperactivated in COVID-19. Circ Res 2020;127:1404-18.
DOI: https://doi.org/10.1161/CIRCRESAHA.120.317703
Bury L, Camilloni B, Castronari R, et al. Search for SARS-CoV-2 RNA in platelets from COVID-19 patients. Platelets 2021;32:284-7.
DOI: https://doi.org/10.1080/09537104.2020.1859104
Real F, Capron C, Sennepin A, et al. Platelets from HIV-infected individuals on antiretroviral drug therapy with poor CD4+ T cell recovery can harbor replication-competent HIV despite viral suppression. Sci Transl Med 2020;12:6263.
DOI: https://doi.org/10.1126/scitranslmed.aat6263
Koupenova M, Corkrey HA, Vitseva O, et al. The role of platelets in mediating a response to human influenza infection. Nat Commun 2019;10:1780.
DOI: https://doi.org/10.1038/s41467-019-09607-x
Simon AY, Sutherland MR, Pryzdial EL. Dengue virus binding and replication by platelets. Blood 2015;126:378-85.
DOI: https://doi.org/10.1182/blood-2014-09-598029
Best MG, Sol N, Kooi I, et al. RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. Cancer Cell 2015;28:666-76.
DOI: https://doi.org/10.1016/j.ccell.2015.09.018
Shen Z, Du W, Perkins C, et al. Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms. Cell Rep Med 2021;2:100425.
DOI: https://doi.org/10.1016/j.xcrm.2021.100425
Gardella JE, Ghiso J, Gorgone GA, et al. Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA. Biochem Biophys Res Commun 1990;173:1292-8.
DOI: https://doi.org/10.1016/S0006-291X(05)80927-1
Canobbio I, Visconte C, Momi S, et al. Platelet amyloid precursor protein is a modulator of venous thromboembolism in mice. Blood 2017;130:527-36.
DOI: https://doi.org/10.1182/blood-2017-01-764910
Sol N, Leurs CE, Veld SGI, et al. Blood platelet RNA enables the detection of multiple sclerosis. Mult Scler J Exp Transl Clin 2020;6:2055217320946784.
DOI: https://doi.org/10.1177/2055217320946784
Margis R, Margis R, Rieder CR. Identification of blood microRNAs associated to Parkinson’s disease. J Biotechnol 2011;152:96-101.
DOI: https://doi.org/10.1016/j.jbiotec.2011.01.023
How to Cite
Bury, L., & Gresele, P. (2022). The amazing genetic complexity of anucleated platelets. Bleeding, Thrombosis and Vascular Biology, 1(2). https://doi.org/10.4081/btvb.2022.33
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