https://doi.org/10.4081/btvb.2022.41

Crosstalk between hemostasis inhibitors and cholesterol biomarkers in multiple sclerosis

Vol. 1 No. 3 (2022)
Submitted: 31 May 2022
Accepted: 8 September 2022
Published: 17 October 2022
Cholesterol, apolipoprotein, heparin cofactor II, hemostasis inhibitor, anticoagulant, multiple sclerosis, coagulation
Abstract Views: 2148
PDF: 217
Supplementary Files: 46
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Authors

Robert Parambi
Department of Pharmaceutical Sciences, State University of New York, Buffalo, United States.
Nicole Ziliotto
https://orcid.org/0000-0003-1007-7266
Department of Pharmacy, University of Pisa, Italy.
Francesco Bernardi
Department of Life Sciences and Biotechnology, University of Ferrara, Italy.
Marcello Baroni
https://orcid.org/0000-0002-2659-6362
Department of Life Sciences and Biotechnology, University of Ferrara, Italy.
Richard W Browne
https://orcid.org/0000-0002-7685-1608
Department of Biotechnical and Clinical Laboratory Sciences, State University of New York, Buffalo, United States.
Dejan Jakimovski
https://orcid.org/0000-0001-7114-4958
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, United States.
Bianca Weinstock-Guttman
https://orcid.org/0000-0001-6732-151X
Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, United States.
Robert Zivadinov
https://orcid.org/0000-0002-7799-1485
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, USA; Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, United States.
Murali Ramanathan
murali@buffalo.edu
Department of Pharmaceutical Sciences, State University of New York, Buffalo; Jacobs Comprehensive MS Treatment and Research Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, United States.

The individual roles of cholesterol pathway biomarkers (CPB) and hemostasis inhibitors with neuroimaging outcomes were previously investigated in multiple sclerosis (MS). The purpose of this extension study was to investigate potential crosstalk between plasma CPB [total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and apolipoproteins (Apo) ApoA-I, ApoAII, ApoB, ApoC-II and ApoE] and hemostasis inhibitors [heparin cofactor-II (HCII), protein C (PC), protein S (PS), thrombomodulin, ADAMTS13 and PAI-1] in a cohort of 127 MS patients, and 40 healthy individuals (HI). The associations were assessed with regressions. In MS patients, HCII was positively associated with TC, LDL-C, HDL-C and ApoA-I (p=0.028, 0.027, 0.002 and 0.027, respectively) but negatively associated with ApoCII (p=0.018). PC was positively associated with ApoC-II (p=0.001) and ApoB (p=0.016) whereas PS was associated with TC (p=0.024) and ApoE (p=0.003) in MS. The ApoC-II associations were not observed in HI. The negative association between ApoC-II and HCll was an exception amongst other positive associations between CPB and hemostasis inhibitors in MS. CPB do not modulate the PC associations with neurodegeneration in MS.

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How to Cite

Parambi, R., Ziliotto, N., Bernardi , F., Baroni , M., Browne , R. W., Jakimovski, D., … Ramanathan, M. (2022). Crosstalk between hemostasis inhibitors and cholesterol biomarkers in multiple sclerosis. Bleeding, Thrombosis and Vascular Biology, 1(3). https://doi.org/10.4081/btvb.2022.41
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