https://doi.org/10.4081/btvb.2022.47
Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia
Submitted: 24 July 2022
Accepted: 25 October 2022
Published: 14 November 2022
Accepted: 25 October 2022
Abstract Views: 1030
PDF: 181
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screening for IT between December 2008 and December 2021 were considered for enrolment. A group of healthy, age-matched women with ≥1 normal pregnancy and no adverse pregnancy outcomes acted as controls. Two hundred and seventeen women were enrolled. The adjusted odds ratio (aOR) of RSA in non-O vs. O blood type was 1.37 (95% CI, 1.04-2.78), and in women with vs. without IT was 1.26 (95% CI, 1.08-3.61); aOR of RSA in women with non-O blood type and IT was 2.52 (95% CI, 1.12-5.47). We observed a significant association between non-O blood group or IT and RSA. The concomitant presence of non-O blood group and IT further increases RSA risk.
Robinson GA. Pregnancy loss. Best Pract Res Clin Obstet Gynaecol 2014;28:169-78.
DOI: https://doi.org/10.1016/j.bpobgyn.2013.08.012
Arias F, Romero R, Joist H, Kraus FT. Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern Fetal Med 1998;7:277-86.
DOI: https://doi.org/10.1002/(SICI)1520-6661(199811/12)7:6<277::AID-MFM5>3.0.CO;2-3
Robertson L, Wu O, Langhorne P, et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006;132:171-96.
DOI: https://doi.org/10.1111/j.1365-2141.2005.05847.x
Middeldorp S. Pregnancy failure and heritable thrombophilia. Semin Hematol 2007;44:93-7.
DOI: https://doi.org/10.1053/j.seminhematol.2007.01.005
Gao H, Tao FB. Prothrombin G20210A mutation is associated with recurrent pregnancy loss: a systematic review and meta-analysis update. Thromb Res 2015;135:339-46.
DOI: https://doi.org/10.1016/j.thromres.2014.12.001
Sergi C, Al Jishi T, Walker M. Factor V Leiden mutation in women with early recurrent pregnancy loss: a meta-analysis and systematic review of the causal association. Arch Gynecol Obstet 2015;291:671-9.
DOI: https://doi.org/10.1007/s00404-014-3443-x
Hamedi B, Feulefack J, Khan A, Sergi C. Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle-Ottawa metaanalysis. Arch Gynecol Obstet 2020;302:345-54.
DOI: https://doi.org/10.1007/s00404-020-05610-6
Klai S, Fekih-Mrissa N, Rachdi R, Gritli N. The status of thrombophilic defects and non-O blood group as risk factors for gestational vascular complications among Tunisian women. Acta Haematol 2011;125:115-20.
DOI: https://doi.org/10.1159/000321934
Akdemir N, Cevrioglu AS, Ozden S, et al. Platelet indices and blood groups in early recurrent miscarriage: a study in pregnant women. J Clin Gynecol Obstet 2013;2:27-30
DOI: https://doi.org/10.4021/jcgo90e
Dentali F, Sironi AP, Ageno W, et al. Non-O blood type is the commonest genetic risk factor for VTE: results from a meta-analysis of the literature. Semin Thromb Hemost 2012;38:535-48.
DOI: https://doi.org/10.1055/s-0032-1315758
Spiezia L, Campello E, Bon M, et al. ABO blood groups and the risk of venous thrombosis in patients with inherited thrombophilia. Blood Transfus 2013;11:250-3.
American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes- 2021. Diabetes Care 2021;44:S15-S33.
DOI: https://doi.org/10.2337/dc21-S002
Campello E, Spiezia L, Adamo A, Simioni P. Thrombophilia, risk factors and prevention. Review Expert Rev Hematol 2019;12:147-58.
DOI: https://doi.org/10.1080/17474086.2019.1583555
Blood type. Available at: http//en.wikipedia.org/wiki/Blood_type. Accessed on: 5 April 2021.
Isermann B, Sood R, Pawlinski R, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003;9:331-7.
DOI: https://doi.org/10.1038/nm825
Wu X, Zhao L, Zhu H et al. Association between the MTHFR C677T polymorphism and recurrent pregnancy loss: a meta-analysis. Genet Test Mol Biomarkers 2012;16:806-11.
DOI: https://doi.org/10.1089/gtmb.2011.0318
Deloughery TG, Hunt BJ, Barnes GD, et al. A call to action: MTHFR polymorphisms should not be a part of inherited thrombophilia testing. Res Pract Thromb Haemost 2022;6:e12739.
DOI: https://doi.org/10.1002/rth2.12739
Franchini M, Crestani S, Frattini F, et al. ABO blood group and von Willebrand factor: biological implications. Clin Chem Lab Med 2014;52:1273-6.
DOI: https://doi.org/10.1515/cclm-2014-0564
Albánez S, Ogiwara K, Michels A, et al. Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms. J Thromb Haemost 2016;14:953-63.
DOI: https://doi.org/10.1111/jth.13294
Marietta M, Facchinetti F, Sgarbi L, et al. Elevated plasma levels of factor VIII in women with early recurrent miscarriage. J Thromb Haemost 2003;1:2536-9.
DOI: https://doi.org/10.1111/j.1538-7836.2003.00496.x
Intzes S, Symeonidou M, Zagoridis K, et al. Hold your needles in women with recurrent pregnancy losses with or without hereditary thrombophilia: Meta-analysis and review of the literature. J Gynecol Obstet Hum Reprod 2021;50: 101935.
DOI: https://doi.org/10.1016/j.jogoh.2020.101935
Lauritsen JG, Grunnet N, Jensen OM. Materno-fetal ABO incompatibility as a cause of spontaneous abortion. Clin Genet 1975;7:308-16.
DOI: https://doi.org/10.1111/j.1399-0004.1975.tb00334.x
How to Cite
Poretto, A., Borella, E., Turatti, G., Marobin, M., Campello, E., Tormene, D., … Spiezia, L. (2022). Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia. Bleeding, Thrombosis and Vascular Biology, 1(3). https://doi.org/10.4081/btvb.2022.47
Copyright (c) 2022 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Most read articles by the same author(s)
- Samantha Pasca, Cristina Santoro, Chiara Ambaglio, Marisanta Napolitano, Marta Milan, Letizia Natali, Silvia Nannizzi, Filippo Mori, Paolo Simioni, Ezio Zanon, Comparison among three different bleeding scores and the thrombin generation assay to assess the different hemorrhagic phenotypes in patients with FVII deficiency , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 2 (2022)
- Paolo Simioni, Vittorio Pengo, Paolo Prandoni, Thrombosis and hemostasis at the University of Padua: a reappraisal on the occasion of its 800th year of history , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 3 (2022)
- Daniela Tormene, Elena Campello, Chiara Simion, Anna Poretto, Paolo Prandoni, Paolo Simioni, Combined oral contraceptives and the risk of venous thromboembolism carriers of antithrombin, protein C or S deficiency: Sub-analysis of a prospective cohort study , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 3 (2022)
- Giovanni Di Minno, Gaia Spadarella, Ilenia Lorenza Calcaterra, Giancarlo Castaman, Paolo Simioni, Raimondo De Cristofaro, Cristina Santoro, Flora Peyvandi, Matteo Di Minno, The evolving landscape of gene therapy for congenital severe hemophilia: a 2024 state of the art , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 2 (2024)
Similar Articles
- Daniela Tormene, Elena Campello, Chiara Simion, Anna Poretto, Paolo Prandoni, Paolo Simioni, Combined oral contraceptives and the risk of venous thromboembolism carriers of antithrombin, protein C or S deficiency: Sub-analysis of a prospective cohort study , Bleeding, Thrombosis and Vascular Biology: Vol. 1 No. 3 (2022)
- Gary E. Raskob, Risk of recurrent venous thromboembolism in cancer patients after discontinuation of anticoagulant therapy , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Bianca Clerici, Mariangela Scavone, Gian Marco Podda, Recent advances in classic heparin-induced thrombocytopenia (HIT), autoimmune HIT, spontaneous HIT, and vaccine-induced immune thrombotic thrombocytopenia , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 2 (2024)
- Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García, Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2 , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 3 (2023)
- Giovanni Di Minno, Gaia Spadarella, Ilenia Lorenza Calcaterra, Giancarlo Castaman, Paolo Simioni, Raimondo De Cristofaro, Cristina Santoro, Flora Peyvandi, Matteo Di Minno, The evolving landscape of gene therapy for congenital severe hemophilia: a 2024 state of the art , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 2 (2024)
- Giovanni L. Tiscia, Donatella Colaizzo, Antonio De Laurenzo, Filomena Cappucci, Lucia Fischetti, Elena Chinni, Mario Mastroianno, Giovanni Favuzzi, Massimo Carella, Elvira Grandone, Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 3 (2024)
- Maria Barca-Hernando, Victor Garcia-Garcia, Luis Jara-Palomares, Location of metastasis and complications in patients with venous thromboembolism and cancer: systematic review , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Yishi Tan, Marc Carrier, Nicola Curry, Michael Desborough, Kathryn Musgrave, Marie Scully, Tzu-Fei Wang, Mari Thomas, Simon J. Stanworth, Cancer complicated by thrombosis and thrombocytopenia: still a therapeutic dilemma , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. s1 (2024): 12th ICTHIC
- Giovanni de Gaetano, Chiara Cerletti, Blood platelets, prostaglandins and aspirin: a historical and personal rereading , Bleeding, Thrombosis and Vascular Biology: Vol. 3 No. 1 (2024)
- Boris Shenkman, Ivan Budnik, Yulia Einav, Interaction between adenosine diphosphate receptors and protein-kinase C isoforms in platelet adhesion under flow condition , Bleeding, Thrombosis and Vascular Biology: Vol. 2 No. 1 (2023)
You may also start an advanced similarity search for this article.
