The clinical usefulness of measuring thrombin generation
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Hemker HC, Béguin S. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemos 1995;74:134-8. DOI: https://doi.org/10.1055/s-0038-1642666
Dargaud Y, Negrier C, Rusen L, et al. Individual thrombin generation and spontaneous bleeding rate during personalized prophylaxis with Nuwiq®(human‐cl rh FVIII) in previously treated patients with severe haemophilia A. Haemophilia 2018;24:619-27. DOI: https://doi.org/10.1111/hae.13493
Dargaud Y, Lienhart A, Janbain M, et al. Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab. Haematologica 2018;103:e181. DOI: https://doi.org/10.3324/haematol.2017.185330
Lebreton A, Sinegre T, Lecompte T, et al. Thrombin generation and cirrhosis: state of the art and perspectives. InSeminars in thrombosis and hemostasis 2020;46:693-703. DOI: https://doi.org/10.1055/s-0040-1715102
Bloemen S, Huskens D, Konings J, et al. Interindividual variability and normal ranges of whole blood and plasma thrombin generation. J Appl Lab Med 2017;2:150-64.
Winckers K, van Hylclama Vlieg A, Thomassen MCLGD, et al. Thrombin Generation and the risk of venous thrombosis: results from a large population-based case-control study. ISTH Toronto 2015.
Bloemen S, Huskens D, Konings J, et al. Interindividual variability and normal ranges of whole blood and plasma thrombin generation. J Appl Lab Med 2017;2:150-64. DOI: https://doi.org/10.1373/jalm.2017.023630
Hron G, Kollars M, Binder BR, et al. Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation. Jama 2006;296:397-402. DOI: https://doi.org/10.1001/jama.296.4.397
Al Dieri R, Peyvandi F, Santagostino E, et al. The thrombogram in rare inherited coagulation disorders: its relation to clinical bleeding. Thromb Haemos 2002;88:576-82. DOI: https://doi.org/10.1055/s-0037-1613258
Azar AJ, Cannegieter SC, Deckers JW, et al. Optimal intensity of oral anticoagulant therapy after myocardial infarction. J Ame Coll Cardiol 1996;27:1349-55. DOI: https://doi.org/10.1016/0735-1097(96)00020-4
Zwaveling S, Bloemen S, Castoldi E, et al. Response of thrombin generation to rivaroxaban in twin-families: influence of sex and contraceptives. Abstract 144150. ISTH congress. Montreal 2023.
Bloemen S, Hemker HC, Al Dieri R. Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation. Haematologica. 2013 Apr;98:549. DOI: https://doi.org/10.3324/haematol.2012.073601
Eikelboom J, Merli G. Bleeding with direct oral anticoagulants vs warfarin: clinical experience. Ame J Med 2016;129:S33-40. DOI: https://doi.org/10.1016/j.amjmed.2016.06.003
Troy A, Anderson TS. National trends in use of and spending on oral anticoagulants among US Medicare beneficiaries from 2011 to 2019. InJAMA Health Forum 2021;2:e211693. DOI: https://doi.org/10.1001/jamahealthforum.2021.1693
Dyer O. Bayer and Janssen pay $775 m to settle Xarelto misinformation claims. BMJ 2019; 364:I1413. DOI: https://doi.org/10.1136/bmj.l1413
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