Blood platelet heterogeneity at a glance: new insights into the relationship between platelet distribution width and neuropsychiatric disorders

Published: 3 May 2023
Abstract Views: 775
PDF: 121
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.


Not available

Lesyk G, Jurasz P. Advances in platelet subpopulation research. Front Cardiovasc Med 2019;6:138. DOI:

Borkataky S, Jain R, Gupta R, et al. Role of platelet volume indices in the differential diagnosis of thrombocytopenia: a simple and inexpensive method. Hematology 2009;14:182-6. DOI:

Handtke S, Thiele T. Large and small platelets - (when) do they differ? J Thromb Haemost 2020;18:1256-67. DOI:

Vagdatli E, Gounari E, Lazaridou E, et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32.

Izzi B, Gialluisi A, Gianfagna F, et al. Platelet distribution width is associated with P-selectin dependent platelet function: results from the moli-family cohort study. Cells 2021;10:2737. DOI:

Izzi B, Gianfagna F, Yang WY, et al. Variation of PEAR1 DNA methylation influences platelet and leukocyte function. Clin Epigenetics 2019;11:151. DOI:

Kar SP, Quiros PM, Gu M, et al. Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. Nat Genet 2022;54:1155-66. DOI:

Izzi B, Tirozzi A, Cerletti C, et al. Beyond haemostasis and thrombosis: platelets in depression and its co-morbidities. Int J Mol Sci 2020;21:8817. DOI:

Yang Y, Zhou Y, Nyholt DR, et al. The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders. Cell Genom 2023;3:100249. DOI:

Astle WJ, Elding H, Jiang T, et al. The allelic landscape of human blood cell trait variation and links to common complex disease. Cell 2016;167:1415-29.e19. DOI:

Nalls MA, Blauwendraat C, Vallerga CL, et al. Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. Lancet Neurol 2019;18:1091-102. DOI:

Gialluisi A, Izzi B, Di Castelnuovo A, et al. Revisiting the link between platelets and depression through genetic epidemiology: new insights from platelet distribution width. Haematologica 2020;105:e246-8. DOI:

Tirozzi A, Izzi B, Noro F, et al. Assessing genetic overlap between platelet parameters and neurodegenerative disorders. Front Immunol 2020;11:02127. DOI:

Tirozzi A, Quiccione MS, Cerletti C, et al. A multi-trait association analysis of brain disorders and platelet traits identifies novel susceptibility loci for major depression, Alzheimer's and Parkinson's disease. Cells 2023;12:245. DOI:

Izzi, B., & Fuster, J. J. (2023). Blood platelet heterogeneity at a glance: new insights into the relationship between platelet distribution width and neuropsychiatric disorders. Bleeding, Thrombosis, and Vascular Biology, 2(2).


Download data is not yet available.