TY - JOUR AU - Poretto, Anna AU - Borella, Elisabetta AU - Turatti, Giacomo AU - Marobin, Michelangelo AU - Campello, Elena AU - Tormene, Daniela AU - Simioni, Paolo AU - Spiezia, Luca PY - 2022/11/14 Y2 - 2024/03/29 TI - Association between non-O blood type and early unexplained recurrent spontaneous abortion in women with and without inherited thrombophilia JF - Bleeding, Thrombosis and Vascular Biology JA - Bleed Thromb Vascul Biol VL - 1 IS - 3 SE - Original Articles DO - 10.4081/btvb.2022.47 UR - https://btvb.org/btvb/article/view/47 SP - AB - <p>We retrospectively evaluated the prevalence of non-O blood type – the most frequently inherited prothrombotic factor – and inherited thrombophilia (IT) in a group of women with recurrent spontaneous abortion (RSA). All consecutive women with a history of early unexplained RSA who underwent a screening for IT between December 2008 and December 2021 were considered for enrolment. A group of healthy, age-matched women with ≥1 normal pregnancy and no adverse pregnancy outcomes acted as controls. Two hundred and seventeen women were enrolled. The adjusted odds ratio (aOR) of RSA in non-O vs. O blood type was 1.37 (95% CI, 1.04-2.78), and in women with vs. without IT was 1.26 (95% CI, 1.08-3.61); aOR of RSA in women with non-O blood type and IT was 2.52 (95% CI, 1.12-5.47). We observed a significant association between non-O blood group or IT and RSA. The concomitant presence of non-O blood group and IT further increases RSA risk.</p> ER -